hat is the role of sialyation in Glycoproteins Choose all the right answers. a. The terminal sialic acid adds a negative charge to the protein. b. Sialylated glycoproteins have a longer circulatory half-life compared to desialylated versions. c. Sialynation of antibodies can affect their biological properties, such as their ability to trigger the immune system d. None of the above

Question

hat is the role of sialyation in Glycoproteins Choose all the right answers. a. The terminal sialic acid adds a negative charge to the protein. b. Sialylated glycoproteins have a longer circulatory half-life compared to desialylated versions. c. Sialynation of antibodies can affect their biological properties, such as their ability to trigger the immune system d. None of the above

Answer 1

The correct answers are:* **a. The terminal sialic acid adds a negative charge to the protein.** Sialic acid is a negatively charged sugar, and its presence on glycoproteins contributes to the overall negative charge of the molecule.* **b. Sialylated glycoproteins have a longer circulatory half-life compared to desialylated versions.** Sialylation helps protect glycoproteins from degradation by enzymes in the bloodstream, leading to a longer half-life.* **c. Sialylation of antibodies can affect their biological properties, such as their ability to trigger the immune system.** Sialylation can influence the binding of antibodies to their targets and their interaction with immune cells.**Therefore, the answer is: a, b, and c.**

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