1) Differentiate between Hodgkin's and non-Hodgkin's lymphoma __ .9mks 2) Structurally, anaemias fall into 4 types. In a table, list the 4 different types, give characteristic of each type and an example of each type __ Managed? __ .6mks PART B (35 Marks) 1. The life of lymphocytes after being released from bone marrow and circulating in blood is of (a) weeks or months.(b) 12 to 25 hours, (c) 3 to 5 hours. (d) 7do 9 hours, (e)8 to 10 hours 2. The life of granulocytes. after being released from bone marrow and circulating in blood is (a) 3 to 5 hours, (b) 1 to 2 hours, (c) 4 to 8 hours, (d)to hours, (e) &to 10 hours 3. The life of monocytes after being released from bone marrow and circulating in blood is (a) 7 to 9 hours, (b) 12 to 25 hours, (c) 3 to hours, (d)10 to 20 hours (e) 8 to 10 hours 4. The white blood cells are formed two majorineages which are (a) lymphoid tissues and granglocytes, (b) myelocytic and lymphocytic lineages, (c ) general tissues and monocytes, (d)special tissues and basophils (e) particular tissues and red blood cells 5. The sites where progenitor dells from the marrow differentiate into mature thymusderived (1) cells in primary lymphoid tissue is (a) the particular tissffes.(b)thedymphoid tissues, (c)the general tissues, (d)the special tissues (c) the thymus, 6. The sites where lymphocytes interact with each other and non-lymphoid cells to generate immune responses to foreign antigen are (a) secondary lymphoid tissues, (b) primary lymphoid tissues, (c) general tissues, (d) Special tissues,(e) particular tissues 7. The sites where lymphocytes develop from progenitor, cells into functional and mature lymphocytes are (a) primary lymphoid tissues, (b)secondary lymphoid tissues, (c)general tissues, (d) special tissues.(e) particular tissues 8. The sites where lymphocytes develop from progenitor cells into functional and mature lymphocyte are (a) primary lymphoid tissues, (b)secondary lymphoid tissues, (c)general tissues, (d) special tissues,(e) particular tissues 9. The lymphoid tissue can be divided into (a) 6, (b) 3 (c) 4, (d) 5 (e) 2, 10. Lymphocytes and plasma cells are formed partially in (a) brain, (b) kidneys,(c) lymphoid (tissue, (d) sebaceous glands (e) endocrine glands

**Part A**<br /><br />1. **Hodgkin's Lymphoma vs. Non-Hodgkin's Lymphoma**<br /><br />| Feature | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma |<br />|---|---|---|<br />| **Cell Type** | Presence of Reed-Sternberg cells (large, abnormal B cells) | Various types of lymphocytes (B cells, T cells, or NK cells) |<br />| **Spread** | Orderly spread from one lymph node group to the next | Can spread in a less predictable manner |<br />| **Symptoms** | Painless swelling of lymph nodes, fever, night sweats, weight loss | Similar to Hodgkin's, but can also include symptoms specific to the affected organ |<br />| **Treatment** | Chemotherapy, radiation therapy, sometimes stem cell transplant | Varies depending on the type and stage; includes chemotherapy, radiation therapy, immunotherapy, targeted therapy |<br /><br /><br />2. **Structural Types of Anemia:**<br /><br />| Type | Characteristic | Example |<br />|---|---|---|<br />| **Microcytic** | Small red blood cells (RBCs), low mean corpuscular volume (MCV) | Iron deficiency anemia |<br />| **Macrocytic** | Large RBCs, high MCV | Vitamin B12 deficiency anemia, folate deficiency anemia |<br />| **Normocytic** | Normal-sized RBCs, normal MCV | Anemia of chronic disease |<br />| **Spherocytic** | Sphere-shaped RBCs | Hereditary spherocytosis |<br /><br /><br />**Part B**<br /><br />1. **(a) weeks or months.** Lymphocytes have varying lifespans, from weeks to years, depending on their type and function.<br /><br />2. **(c) 4 to 8 hours.** Granulocytes, specifically neutrophils, have a relatively short lifespan in circulation.<br /><br />3. **(d) 10 to 20 hours.** Monocytes circulate in the blood for a short period before migrating to tissues and differentiating into macrophages.<br /><br />4. **(b) myelocytic and lymphocytic lineages.** Hematopoiesis, the formation of blood cells, involves these two main lineages.<br /><br />5. **(e) the thymus.** T cells mature in the thymus.<br /><br />6. **(a) secondary lymphoid tissues.** These tissues, such as lymph nodes and spleen, are where lymphocytes encounter antigens and initiate immune responses.<br /><br />7. **(a) primary lymphoid tissues.** These include the bone marrow (for B cells) and thymus (for T cells).<br /><br />8. **(a) primary lymphoid tissues.** This is a repeat of question 7.<br /><br />9. **(e) 2.** Lymphoid tissue is broadly classified into primary and secondary lymphoid tissues.<br /><br />10. **(c) lymphoid tissue.** Lymphocytes and plasma cells are primarily formed and mature within lymphoid tissues.<br />